Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Songtao Zhang,Dongzhi Xue,Xiaoqing Li,Jianhua Liu,Ying Zhao,Hongjie Zhang,Tianqi Zhang,Rui Niu,Na Yin,Yinghui Wang,Yang Liu,Longhai Jin,Shuyan Song

doi:10.1007/s40820-020-00516-z

Abstract

HighlightsThe MoS2 nanosheets served as co-catalyst could reduce Fe3+ ions with lower Fenton reaction activity into the highly reactive Fe2+ ions, thereby boosting the production of hydroxyl radical (•OH) for high efficiency chemodynamic therapy (CDT).The photothermal effect of MoS2 nanosheets motivated by second near-infrared light could further improve the treatment effectiveness by synergetic photothermal-enhanced CDT and photothermal therapy.

Highlights

Nowadays, cancer is an illness which threatens the human health owing to its high mortality rate and recurrence rate [1, 2]
The MoS2 nanosheets with average size of 150 nm were obtained after sonicating the solution of large MoS2 sheets (> 1 μm) which is shown in Fig. 1a, b, and as shown in Fig. S1a, the X-ray diffraction (XRD) pattern can be indexed well to 2H–MoS2 phase (JCPDS No 37-1492)
The energy dispersive X-ray (EDX) mappings shown in Fig. 1e confirm the chemical composition of FeO/MoS2-bovine serum albumin (BSA) nanocomposites

Summary

Introduction

Cancer is an illness which threatens the human health owing to its high mortality rate and recurrence rate [1, 2]. Our group has successfully utilized the light, ultrasound, and near-infrared II (NIR II) light-triggered photothermal effect to assist the Fenton reaction and improve the treatment effect. In addition to these methods that depend on the external stimulus to enhance the Fenton reactions efficiency [16, 17], the strategy that introduces a catalyst to accelerate the rate-controlling step of F e3+/Fe2+ conversion has been attracted much more attentions recently in the field of treating persistent pollutants [18, 19]. If the catalyst has good photothermal performance response to NIR II light for PTT, the improved therapeutic efficacy of CDT will be achieved through the synergistic effect

Methods

Results

Conclusion