Abstract
We report the case of a 51-year-old non-smoking man who presented with flu-like symptoms and patchy, migratory infiltrates as evidenced on a chest-X ray. No res ponse to antibiotic therapy was noted. Transbronchial lung biopsy revealed BOOPlike reaction associated with histopathology characteristic of pulmonary histioc ytosis X. Immunoperoxidase stain showed histiocytic cells being positive for S100 protein and CD1a. Along with the Langerhans cell proliferation, a bronchioli tis obliterans organizing pneumonia-like reaction was noted. In this paper, we d iscuss in this patient medical course and the clinical and pathologic characteri stics of this unusual presentation of pulmonary histiocytosis X.
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