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Abstract
Book review: “Glial physiology and pathophysiology” by Alexei Verkhratsky and Arthur Butt, Wiley-Blackwell, 2013
Highlights
The textbook “Glial Physiology and Pathophysiology” by Alexei Verkhratsky and Arthur Butt is aimed at researchers and clinicians as a detailed and comprehensive source of readily obtainable information
This paper shows that in the case of astrocytes, primary cultures can be prepared in such a way that they provide correct information, as indicated by 100% identical results in cultures used by this group and freshly isolated cells, when comparisons were made
Two specific systems are critically dependent upon interactions between astrocytes and neurons and are discussed in some detail: The glutamatergic/GABAergic system utilizes exclusively glutamate formed from glucose by astrocytes, conversion of glutamate to glutamine, which has no transmitter activity, transfer of glutamine from astrocytes to neurons in the glutamine glutamate(GABA)-glutamine cycle, and exocytotic release from neurons
Summary
The textbook “Glial Physiology and Pathophysiology” by Alexei Verkhratsky and Arthur Butt is aimed at researchers and clinicians as a detailed and comprehensive source of readily obtainable information. It addresses readers wanting to get a systematic, brief and correct overview of glial function in healthy and diseased brain. It is difficult to obtain correct information about glial functions because of less than perfect means to study these functions.
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