Abstract
This is a review of a recently published book entitled 'Alzheimer's Disease Research: What has guided research so far and why it is high time for a paradigm shift' by Christian Behl, a leading contributor to the field of Alzheimer disease over the last three decades. It presents a personal viewpoint on the historical developments in dementia research and therapeutics from its early beginnings through to the current day. The conflicting hypotheses, the therapeutic trials, the successes and the failures of the vast research infrastructure devoted to dissecting the aberrant pathways underlying the inexorable progression of this ultimately fatal neurodegenerative disease are discussed. It is based, among others, on numerous personal discussions of the author with other leading researchers in the field, and thus gives this (hi)story of Alzheimer research a personal touch and spotlight on controversies that distinguishes it from other books in the field.
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