Abstract
Objectives: To establish reference ranges for serum bone turnover markers including Osteocalcin (OC), Procollagen type 1 amino-terminal propeptide (P1NP), and Beta-CrossLaps (beta-CTX) in premenopausal women at University Medical Center, Ho Chi Minh City. Methods: A cross-sectional study was conducted on 157 women aged 20 to 44 years at University Medical Center, Ho Chi Minh City from December 2022 to February 2023. Demographic information, biochemical markers, and serum levels of OC, P1NP, and beta-CTX were recorded. Results: The mean serum levels of OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively. The levels of bone turnover markers varied significantly among different age groups (p < 0.01). Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age, with r values of -0.44, -0.35 and -0.43 respectively (p < 0.01). Conclusion: The reference ranges for serum markers of bone turnover including OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively, in premenopausal women aged 20 to 44 years. Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age in a moderate degree Key words: osteocalcin, P1NP, beta-CTX, bone turnover markers, premenopausal women.
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