Abstract
A bone tissue phantom prototype allowing to test, in general, optical flowmeters at large interoptode spacings, such as laser-Doppler flowmetry or diffuse correlation spectroscopy, has been developed by 3D-stereolithography technique. It has been demonstrated that complex tissue vascular systems of any geometrical shape can be conceived. Absorption coefficient, reduced scattering coefficient and refractive index of the optical phantom have been measured to ensure that the optical parameters reasonably reproduce real human bone tissue in vivo. An experimental demonstration of a possible use of the optical phantom, utilizing a laser-Doppler flowmeter, is also presented.
Highlights
Tissue blood flowmetry based on non-invasive optical techniques, such as laser-Doppler flowmetry (LDF) at large interoptode spacings [1,2,3,4,5] or diffuse correlation spectroscopy (DCS) [6,7,8], is a unique tool allowing investigating particular physiological phenomena in humans that are not accessible with other known techniques
It has been shown that 3D stereolithography can be used to build optical phantoms (OP) for optical flowmeters
The ‘uniform’ OP geometry chosen in the present contribution is at the bases of the majority of the algorithms implemented in the LDF and DCS hardware
Summary
Tissue blood flowmetry based on non-invasive optical techniques, such as laser-Doppler flowmetry (LDF) at large interoptode spacings [1,2,3,4,5] or diffuse correlation spectroscopy (DCS) [6,7,8], is a unique tool allowing investigating particular physiological phenomena in humans that are not accessible with other known techniques (see note [9]). Thanks to these unique capabilities, it has been possible for example to realize original investigations on the thermoregulatory processes modulating the blood flow of small muscle masses in humans [10] or to observe blood flow pulsations in human bones [11, 12] In this frame, one of the technical challenges that remains to be solved is the calibration and the testing of the optical flowmeters with suitable optical phantoms (OP). One of the technical challenges that remains to be solved is the calibration and the testing of the optical flowmeters with suitable optical phantoms (OP) It appears that it is extremely difficult to produce an OP that reproduces the complex vascular structure of a biological tissue, where the vessels diameter may vary over many orders of magnitude. Attempts in this direction have been limited until now to OP based on the Brownian movement of liquids with no real vascular structure [13], or to OP containing simple straight canals [2] due to the difficulty of creating complex curved structures with varying diameters
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
