Abstract
Purpose: Hypertrophic differentiation of chondrocytes in osteoarthritis (OA) is a pathological process leading to vascularization and mineralization of the cartilage. The pathogenesis of OA is thought to reiterate changes that occur during endochondral ossification in which angiogenesis is required to initiate chondrocyte hypertrophic differentiation. We previously demonstrated that Bone Sialoprotein (BSP) production is associated with chondrocyte hypertrophy and the severity of osteoarthritic lesions.
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