Abstract
The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with β-tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCPTM (HA:β-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material.
Highlights
Bone graft materials are in high demand for the replacement of bone tissues due to accidents, diseases, or other implantation needs
Si-HA mixed mixed with with various various ratio ratio of of β‐tricalcium phosphate (TCP), β-tricalcium phosphate (β-TCP), we we evaluate evaluate its its bioactivity bioactivity
< 0.05), there were no significant differences among the MBCP, S100T0, S70T30, and S50T50
Summary
Bone graft materials are in high demand for the replacement of bone tissues due to accidents, diseases, or other implantation needs. The coral genus Goniopora was used as raw material. It hasItahas porous structure and the are interconnected similar to bone. Silicon is elements onon earth andand it isitanisimportant element in theinbody It has been detected in cartilage and other connective tissues [8]. Si is known as a key element early stages of the biomineralization process and it was reported as an inducer [9,10,11,12,13]. The objective objective of of this this study study was was to to evaluate evaluate osteoconductivity osteoconductivity of of new new bone bone graft graft in material groups in a bone-defect model.
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