Abstract
Nowadays, regenerative medicine has paid special attention to research (in vitro and in vivo) related to bone regeneration, specifically in the treatment of bone fractures or skeletal defects, which is rising worldwide and is continually demanding new developments in the use of stem cells, growth factors, membranes and scaffolds based on novel nanomaterials, and their applications in patients by using advanced tools from molecular biology and tissue engineering. Strontium (Sr) is an element that has been investigated in recent years for its participation in the process of remodeling and bone formation. Based on these antecedents, this is a review about the Strontium Folate (SrFO), a recently developed non-protein based bone-promoting agent with interest in medical and pharmaceutical fields due to its improved features in comparison to current therapies for bone diseases.
Highlights
The rise in the average age of the population has led to a steady increase in the number of musculoskeletal conditions and in particular of cartilage and bone surgical procedures in the last years [1,2]
A three-dimensional (3D) biohybrid scaffold based on calcium phosphate and a bio-active derivative of Vitamin-B and Sr (Strontium Folate, Sr folate (SrFO)) was developed
Stem cells are generally defined as clonogenic cells capable of self-renewal; these are non-specialized cells that renew by cell division with the remarkable ability to differentiate to a specific cellular type [34,35,36]
Summary
The rise in the average age of the population has led to a steady increase in the number of musculoskeletal conditions and in particular of cartilage and bone surgical procedures in the last years [1,2]. The scaffold must be composed of materials that stimulate and favor the formation of new bone tissue as well as to be structurally stable during the process of cell growth and expansion [3]. A three-dimensional (3D) biohybrid scaffold based on calcium phosphate and a bio-active derivative of Vitamin-B and Sr (Strontium Folate, SrFO) was developed This device induced the healing of critical-sized cranial defects in rats using human dental pulp stem cells (HDPSCs) without the addition of exogenous growth factors. Xu et al demonstrated that strontium folic acid derivatives promote in vitro the osteogenic differentiation of MSCs shortly after addition; especially in the long term Such derivatives improved significantly bone formation around the bio-functional orthopedic implants in vivo, which was highly evident at late stages [17]
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