Abstract
Development of a unicellular zygote to a multilayered organised embryo, involves complex growth cues from specific growth factors...
Highlights
Bone morphogenetic proteins (BMPs) are essential factors in regulating cell differentiation, proliferation, motility, and survival during embryonic, postnatal development, and tissue development
Aberrant expression of BMPs is implicated in multiple cancer studies suggesting a role in tumorigenesis and promoting cancer progression in different stages
BMP4 is implicated in mouse ES cell self- renewal and regulating fate choices during stem cell differentiation [12]
Summary
Bone morphogenetic proteins (BMPs) are essential factors in regulating cell differentiation, proliferation, motility, and survival during embryonic, postnatal development, and tissue development. Aberrant expression of BMPs is implicated in multiple cancer studies suggesting a role in tumorigenesis and promoting cancer progression in different stages. First known for their ability to induce bone formation, members of Bone Morphogenetic Proteins (BMPSs) are known to play crucial roles in in the regulation of a multiple developmental processes including formation of meso and endodermal lineages [2,3,4] and PGC specification [5,6,7] during early embryonic development.
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