Abstract
Gonadotropins are secreted by the pituitary gland and delivered to the ovary through the blood vessels. Angiogenesis plays a crucial role in the follicular growth. During the follicular development, vasculature of the follicle is limited to the theca cell (TC) layer outside the basement membrane. Although angiogenesis in the TC layer is important, the mechanism is unclear. BMP cytokines are known to be important during folliculogenesis in human. BMP7 is expressed in the TC layer in ovary. We investigated the function of BMP7 in regulating angiogenesis in human ovary.
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