Abstract
Using a tissue culture system, the mineralization of both whole and longitudinally split chick embryo tibiae was shown to be directly related to the Ca/PO4 ratio of the medium when the Ca × PO4 product was constant. However, with increasing Ca levels in the medium, mineralization of the split bones was more extensive than that of the intact bones. Lactate production by the split tibiae was independent of the Ca/PO4 ratio of the medium and was less than the Ca/PO4 ratio-dependent production by the intact bones. All of the cultured bones showed an increase in total nitrogen that was independent of either splitting or Ca/PO4 ratios in the medium. The results of this study support the recent concept of a metabolically active bone membrane.
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