Abstract
Indirect micro-architectural (MA) approximation is evaluable in daily practice by the Trabecular Bone Score (TBS) measure. The aim of the OsteoLaus cohort is to combine CRF and the information given by DXA (bone mineral density [BMD], TBS and vertebral fracture assessment [VFA]) to better identify women at high fracture risk. We included 631 women: mean age 67.4 ± 6.7 y, BMI 26.1 ± 4.6. Correlation between BMD and site matched TBS was low (r2 = 0.16). Prevalence of vertebral fractures (VFx) grade 2/3, major OP Fx and all OP Fx was 8.4 %, 17.0 % and 26.0 % respectively. Ageand BMI-adjusted ORs (per SD decrease) were 1.8 (1.2–2.5), 1.6 (1.2–2.1), 1.3 (1.1–1.6) for BMD and 2.0 (1.4–3.0), 1.9 (1.4–2.5), 1.4 (1.1–1.7) for TBS respectively.
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