Bone mineral density assessed by dual energy X-ray radiography in patients with alcoholic or HBV-related liver cirrhosis

Abstract

Objective To investigate the differences of bone mineral density( BMD) among the patients with alcoholic or HBV-related liver cirrhosis,and healthy controls. Methods Dual-energy X-ray radiography was employed to determine the BMD of he lumbar vertebra and bilateral hip joints in 57 patients with alcoholic cirrhosis,67 with hepatitis B cirrhosis,and 175 healthy controls. The demographic data and clinical characteristics( hepatic fibrosis and hepatic function) of all the participants were collected. Independent sample t-test was used to compare the differences among 3 groups and multiple classified logistical regression analysis was used to evaluate factors influencing BMD. Results The BMD of alcoholic cirrhosis and HBV-related cirrhosis patients were significantly lower than that of healthy controls( P 0. 01),and the BMD in alcohol cirrhosis patients was significantly lower than that in HBV-related cirrhosis patients( P 0. 05). Univariate logistic regression analysis identified that female gender,elder age,liver cirrhosis degree,and liver function were significantly correlated with the levels of BMD( P 0. 01). Multivariate analysis showed that alcoholic cirrhosis( OR = 2. 053,95% CI = 1. 931-3. 852) and HBV-related cirrhosis( OR = 1. 521,95% CI = 1. 342-2. 354) were the independent risks of reduced BMD in patients. Conclusion BMD levels of patients with alcoholic cirrhosis and HBV-related cirrhosis are significantly lower than that of the healthy controls,and hepatic cirrhosis is independent factor of osteoporosis.