Bone mineral density and vitamin D levels in parkinson’s disease: A retrospective controlled study

Abstract

Aim: This study aimed to compare bone mineral density and vitamin D levels in patients with Parkinson’s Disease (PD) and healthy controls.Methods: Eighty-six patients aged 60-85, diagnosed with PD and receiving regular medical treatment for the disease were screened. Data for 34 participants (19 women and 15 men) meeting the inclusion criteria were entered into the retrospective analysis. The data for 31 healthy age- and sex-matched participants (18 women and 13 men) were also included. Bone mineral density (BMD) values and vitamin D levels of each participant were recorded.Results: BMD values for the femoral neck and total hip in the PD group were statistically significantly lower than healthy controls. In addition, T-scores for the femoral neck, total hip, and trochanteric area, and Z-scores for the total hip and trochanteric area were also lower in the patients with PD than in the healthy controls. The two groups did not have significant differences regarding lumbar spinal BMD measurements and T- and Z-score values or vitamin D levels.Conclusion: PD’s total hip and femoral neck BMD measurements are low. Further multicenter studies involving larger patient populations are now needed to understand the incidence and mechanisms of osteoporosis in PD.