Abstract
Background Parathyroid function and bone mineral density (BMD) in β–thalassemia major (β-TM) patients are provided. Some recent suggestions are presented about the cellular and structural changes in thalassemia bones. Aim The current work aims to study BMD and related mineral and hormonal profiles in β-TM cases and its relation to the sex and age strata of the patients. Patients and methods The study includes 30 healthy control and 55 β-TM patients who were divided into subgroups according to age and sex. Parathormone (PTH), ferritin, and calcium were investigated. The dual-energy radiography absorptiometry were used to the assessment of BMD. Results Serum ferritin level was as expected significantly elevated in β-TM cases. Serum PTH was significantly lower in β-TM cases when matched with healthy control. Serum calcium was within normal in β-TM. BMD of lumber spine in β-TM was markedly detracted when matched with the healthy normal group. 76% of our cases showed reduced BMD. Conclusion BMD is reduced in 76% of β-TM. PTH is reduced in all age strata of β-TM.
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