Abstract
BackgroundOligodendroglioma is a rare type of primary brain tumor which, like other malignant gliomas, metastasizes very rarely even when in high-grade form.Case reportA 36-year-old white man diagnosed 29 months previously as having 1p/19q codeleted anaplastic oligodendroglioma presented bilateral cruralgia and lower limb motor deficits. A computed tomography scan showed multiple osteoblastic bone lesions. The presence of oligodendroglial cells was revealed by bone marrow biopsy and confirmed by immunohistochemical analyses. A positon emission tomography-computed tomography scan confirmed the exclusive involvement of bones.ConclusionThis case joins less than 20 other reported cases of oligodendroglioma bone marrow metastasis, and is one of only a handful of cases of diffuse bone metastases beyond the axial skeleton. To the best of our knowledge, the early relapse of 1p/19q codeleted anaplastic oligodendroglioma with this distribution of metastases has never been described in the literature.
Highlights
Oligodendroglioma is a rare type of primary brain tumor which, like other malignant gliomas, metastasizes very rarely even when in high-grade form.Case report: A 36-year-old white man diagnosed 29 months previously as having 1p/19q codeleted anaplastic oligodendroglioma presented bilateral cruralgia and lower limb motor deficits
It has generally been thought that primary brain tumors rarely metastasize, and that these rare cases only occur inside the central nervous system (CNS)
We report a case of bone metastases from a 1p/19q codeleted and IDH1-mutant anaplastic oligodendroglioma 29 months after first diagnosis of a brain tumor
Summary
The novelty of this case lies in the early occurrence of metastatic evolution in a sub-type of oligodendroglioma that habitually has a good prognosis, the singular distribution of metastases, and the different mechanisms that may play a role in tumor cell diffusion
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