Abstract

A 47-year-old woman had brain surgery for a metastatic brain tumor, which was a poorly differentiated adenocarcinoma. Chest radiograph demonstrated a lesion (2 cm in diameter) in the right upper lung field. Both Tc-99m (V) DMSA and Tc-99m HMDP scintigraphy demonstrated multiple areas of increased uptake in the osseous structures. Although there was almost no uptake in the uninvolved bone, the uptake in the ribs was slightly less visible on Tc-99m (V) DMSA images than Tc-99m HMDP images because of increased background activity in the heart, liver, spleen, kidneys, and major vascular structures. Tc-99m(V) DMSA showed less accumulation in the postsurgical changes of the skull than did Tc-99m HMDP. Pentavalent Tc-99m DMSA may specifically accumulate in active osseous lesions but less so in the joints, surrounding normal bone, and reactive osseous changes. This may suggest that Tc-99m (V) DMSA accumulation is specific for tumor in osseous structures.

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