Bone metastases (BM) in patients (pts) with locally advanced or metastatic gastric cancer (AGC): Clinical and therapeutic implications.

Abstract

e15006 Background: At diagnosis BM occur in approximately 10-15% of AGC pts and their prognosis is poor (Park 2011; Silvestris 2013). Aim of this study is to identify the main features of pts with AGC and BM at diagnosis together with their response to chemotherapy and clinical course. Methods: We reviewed the clinical records of all AGC pts followed at Cremona Oncology Division from November 2004 to January 2013 and included in three consecutive prospective trials (Dalla Chiesa M. 2011; Tomasello G. 2013). We compared pts with BM at diagnosis vs pts without BM. All pts received a first linetherapy with TCF-dd regimen + Pegfilgrastim. Baseline clinical and pathological parameters were evaluated, together with Overall Survival (OS), Response Rate (RR), Time to Progression (TTP), Time From first Progression to Death (TFPTD), and toxicity. Analysis was based on the intention to treat principle. Results: 151 AGC pts were identified: 21 with BM and 130 without BM.The presence of non-bone metastases was balance...