Abstract
Bone marrow contains hematopoietic stem cells (HSCs) and nonhematopoietic cells. HSCs are self-renewing multipotent progenitors that give rise to all types of mature blood cells, whereas the nonhematopoietic component is composed of osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T lymphocytes, macrophages, mast cells, fibroblasts and mesenchymal stem cells. All of these cells contribute to the formation of specialized ‘niches’, which are close to the marrow vasculature (‘vascular niche’) or to the endosteum (‘osteoblast niche’).1 Depletion of either osteoblasts or endothelial cells is negatively associated with HSC survival, suggesting that both niches are important for maintaining HSC.2, 3
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