Abstract
SummaryAfter whole-body exposure to fast neutrons of high LET in the lethal dose-range (LD50/30 d 351 ± 2 rads) male mice of the inbred CBA strain die mostly between 8 and 15 days after irradiation. Death is mainly due to haematopoietic damage, as evidenced by the protection afforded by syngeneic bone-marrow transplantation. By increasing the neutron dose into the supralethal range, the effectiveness of bone-marrow therapy is decreased by the growing prevalence of the intestinal syndrome (LD50/5 d 452 ± 4 rads). Female mice have the same sensitivity as regards haematopoietic damage (LD50/30 d 348 ± 2 rads) but are slightly more sensitive to intestinal injury (LD50/5 d 423 ± 3 rads). In spite of the bone-marrow transplantation, the probability of death between 10 and 15 days also increases with neutron dose, presumably as a result of the severe damage to the gastric epithelium, which appears at the same time.
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