Bone marrow stromal cells as a therapeutic treatment for cerebral ischemic

Abstract

Bone marrow stromal cells (BMSCs) are a kind of stem cells with multiple differentiation potential in bone marrow. BMSCs have been widely used in tissue engineering, cell transplantation, gene therapy and organ transplantation, due to their characteristics of wide range of sources, weak immunogenicity weak, easily transfected by exogenous gene, long survival time in the host, multi-directional differentiation, etc. Cerebral ischemia is caused by neurological impairment, which is the most common cause of death and quality-of-life impairments. The clinical manifestations of the patients with cerebral ischemia are motor function failure, sensory dysfunction and abnormal mental consciousness. A large number of studies have reported that BMSCs transplantation has the therapeutic effects of body sensory and motor function recovery, and can treat ischemic stroke. BMSCs transplantation has brought new hope for the clinical treatment of ischemic cerebrovascular disease. In this paper, the recent progress in the study of BMSCs transplantation for ischemic stroke was reviewed. The mechanism, pathways, influencing factors and clinical application of BMSCs transplantation were summarized. Key words: Bone marrow stromal cell; Transplantation; Cerebral ischemia