Abstract
Whole-body exposure to a given dose of 250-kV X-rays (100 rads or 300 rads) induced greater cell depletion in the left femoral marrow of RFM/U mice than irradiation of the left femur alone. This is consistent with the concept that tissue damage produced by whole-body irradiation is due to a combination of direct and systematic injury. It is postulated that the systematic injury results from the suppression of protection afforded by the unirradiated tissues rather than from toxic agents emerging in the irradiated tissues. The loss of the nucleated cells (erythroblasts, lymphoid and myeloid precursor cells, mature myeloid cells) in the marrow of the irradiated left femur was paralleled by an increase in the number of marrow erythrocytes, so that the total count (nucleated cells plus erythrocytes) remained constant throughout the period of acute radiation injury. Both the nucleated cell response and the erythrocyte response were highly dose-dependent. Hence, the ratio of erythrocytes over nucleated cells, which can be estimated from a marrow biopsy variable and unpredictable size, may be useful as a biological dosimeter in estimating the radiation dose received by an individual.
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