Abstract
Background: It has been shown that autologous bone marrow cells may contribute to myocardial repair after acute myocardial infarction. The aim of this study was to assess the beneficial effects of intracoronary transplantation of bone marrow cells in patients (n=9) with chronic ischemic cardiomyopathy. Methods: Bone marrow was obtained and the cells were injected intracoronary after a brief balloon occlusion at a normal coronary segment. Dobutamine stress echo showed that all patients had left ventricular ejection fraction < 35%. Patients were followed up to 12 month. Clinical follow up was performed periodically and included electrocardiography, laboratory tests and echocardiography. Results: Intracoronary bone marrow cell therapy improved ventricular performance, quality of life and survival in patients with chronic ischemic cardiomyopathy. No side effects were observed Conclusions: Intracoronary transplantation of autologous bone marrow cells is safe and feasible in chronic ischemic cardiomyopathy.
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