Abstract
In the last 20 years, the modern anti-myeloma drugs and autologous stem cell transplant (ASCT) significantly improved prognosis of multiple myeloma (MM) patients. Despite high efficiency of current induction regimens, most patients relapse over time. The link between changes in the immune system and prognosis of the disease is still not entirely clear. Therefore, we analyzed whether the reconstructive pattern of bone marrow (BM) lymphocytes during routine BM examination after ASCT is related to disease prognosis and whether there is a typical reconstructive pattern in patients with MRD negative complete remission.
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