Abstract
Introduction A recent attractive option regarding mesenchymal stem cells (MSC) application is the treatment of bone cystic lesions and in particular aneurysmal bone cysts (ABC), in order to stimulate intrinsic healing. We performed a retrospective evaluation of the results obtained at our institution. Methods The study group consisted of 46 cases with an average follow-up of 33 months. Forty-two patients underwent percutaneous treatment as the first approach; four patients had curettage as first treatment. In all cases, autologous bone marrow concentrate (BMC) was associated too. The healing status was followed up through a plain radiograph 45 days and 2 months after the procedure. Results and Conclusions. At the final follow-up, thirty-six patients healed with a Neer type II aspect, nine healed with a type I aspect, and one patient was not classified having total hip arthroplasty. Bone marrow concentrate is easy to obtain and to manipulate and can be immediately available in a clinical setting. We can assert that the use of BMC must be encouraged being harmless and having an unquestionable high osteogenic and healing potential in bone defects.
Highlights
A recent attractive option regarding mesenchymal stem cells (MSC) application is the treatment of bone cystic lesions and in particular aneurysmal bone cysts (ABC), in order to stimulate intrinsic healing
In the past 30 years, many studies have confirmed the potentials and plasticity of the so-called mesenchymal stem cells (MSC): they have been shown to reside within the connective tissues of most organs and can differentiate into osteogenic, adipogenic, and chondrogenic lineages under appropriate conditions [1,2,3]
We performed a retrospective evaluation of the results obtained at our institution after aneurysmal bone cyst percutaneous treatment with application of bone marrow concentrate (BMC) in order to understand if the use of bone marrow stem cells gives benefits
Summary
A recent attractive option regarding mesenchymal stem cells (MSC) application is the treatment of bone cystic lesions and in particular aneurysmal bone cysts (ABC), in order to stimulate intrinsic healing. In the past 30 years, many studies have confirmed the potentials and plasticity of the so-called mesenchymal stem cells (MSC): they have been shown to reside within the connective tissues of most organs and can differentiate into osteogenic, adipogenic, and chondrogenic lineages under appropriate conditions [1,2,3] These features have led to an increasing application of MSC in the orthopaedic field, especially when a strong regenerative capacity applied through a minimally invasive approaches is required. We performed a retrospective evaluation of the results obtained at our institution after aneurysmal bone cyst percutaneous treatment with application of BMC in order to understand if the use of bone marrow stem cells gives benefits
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
