Bone marrow abnormalities detected by magnetic resonance imaging as initial sign of hematologic malignancies.

Ida Sofie Grønningsæter,Silje Johansen,Aymen Bushra Ahmed,Håkon Reikvam,Øystein Bruserud,Nils Vetti

doi:10.4081/cp.2018.1061

Ida Sofie Grønningsæter, Silje Johansen + Show 4 more

Open Access

https://doi.org/10.4081/cp.2018.1061

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Abstract

The increasing use of radiological examination, especially magnetic resonance imaging (MRI), will probably increase the risk of unintended discovery of bone marrow abnormalities in patients where a hematologic disease would not be expected. In this paper we present four patients with different hematologic malignancies of nonplasma cell types. In all patients the MRI bone marrow abnormalities represent an initial presentation of the disease. These case reports illustrate the importance of a careful diagnostic follow-up without delay of patients with MRI bone marrow abnormalities, because such abnormalities can represent the first sign of both acute promyelocytic leukemia as well as other variants of acute leukemia.

Highlights

Case #2 A previously healthy 21-year-old man presented with a 6-month history of pain in the left buttock, as well as deep in the upper left thigh, and intermittent episodes of night sweats
This report describes four different cases of hematologic malignancies, in which the malignancy was not suspected based on the absence of symptoms and clinical signs and normal peripheral blood cell ly counts
magnetic resonance n imaging (MRI) has become a preferred e diagnostic imaging modality for an increass ing number of diseases,[4] which is likely to u result in an increased detection rate of incidental findings showing bone marrow l abnormalities.[4]

Summary

Introduction

Case #2 A previously healthy 21-year-old man presented with a 6-month history of pain in the left buttock, as well as deep in the upper left thigh, and intermittent episodes of night sweats. Signal abnormalities suggesting bone marrow edema in the pelvis were detected posteriorly in the left iliac crest and spreading forward in the iliac bone along the sacroiliac (SI) joints malignant cells shows characteristic pat- reaction (PCR), respectively. Disease control was not edema was found in the medial gluteal malignancies in which abnormal MRI find- achieved, with a decrease in normal periph- muscle, adjacent to the iliac crest.

Results

Conclusion