Abstract
In this study, mussel-inspired polydopamine nanospheres (∼400 nm) were synthesized via spontaneous oxidative polymerization of dopamine hydrochloride. The creation of bioactive template provided an opportunity for the biomimetic formation of hydroxyapatite layers through soaking of polymeric samples in 10 × -simulated body fluid (10 × -SBF) solution and heating microwave radiation. According to the results, microwave irradiation supported the rapid and homogeneous formation of HA on the surface of bioinspired spheres, and synthesized HA showed nearest Ca/P ratio to biological HA. In addition, Fourier transform infrared spectrum, X-ray diffraction, and atomic force microscopy tests confirmed the effectiveness of microwave rays on biomimetic mineralization. Biocompatibility of the constructs and improving cellular spreading on the HA-coated species indicated their potential for biomedical applications.
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