Abstract
Few articles have shown changes in bone metabolism caused by hypertension. The objective of this study was to investigate the relationship between hypertension and bone healing. Circular critical-size defects 5 mm and 2 mm in diameter were created, respectively, on the left and right side of the mandible in 40 spontaneously hypertensive and 40 control Wistar-Kyoto rats. Five animals from each strain were killed 2, 3, 5, 10, 15, 30, 60 and 90 days after surgery. The macroscopic evaluation showed great mandibular angle deformation on the left side and non-healed defects on both sides and groups. Histological evaluation revealed similar bone healing on both sides, with initial necrosis in the central area, and fibrosis and angiogenesis within the first 5 days. From the 10th postoperative day on, the newly formed bone displayed progressive thickening until the 90th postoperative day, when the defect margins presented a compact bone structure. Furthermore, the statistical analysis of the histometric data did not reveal any significant hypertension effect on bone healing in the defect area. These results suggest that bone healing was not different between spontaneously hypertensive rats and control rats.
Highlights
According to a World Health Organization (WHO) report, one in three adults worldwide has raised blood pressure, and the projections for 2025 are that one third of all adults will have this condition.[1,2] Hypertension is important because of its high prevalence, and because it is an asymptomatic disease whose diagnosis and treatment are frequently delayed
5 animals died in the Wistar-Kyoto rats (WKY) group and 4 animals died in the spontaneously hypertensive rats (SHR) group
Gross macroscopy In both groups, WKY and SHR, a great bone deformation was observed on the left side, which became evident as of the 30th postoperative day (POD)
Summary
According to a World Health Organization (WHO) report, one in three adults worldwide has raised blood pressure, and the projections for 2025 are that one third of all adults will have this condition.[1,2] Hypertension is important because of its high prevalence, and because it is an asymptomatic disease whose diagnosis and treatment are frequently delayed. Abnormalities in calcium metabolism have been associated with essential hypertension, but the results are controversial. Hypercalciuria and a higher calcium/creatinine ratio are found mainly in osteoporotic groups, but bone mineral density (BMD) and osteoporosis percentages in the postmenopausal period are similar between hypertensive and normotensive women.[3] Urinary calcium excretion is inversely correlated to BMD, whereas serum total and ionized calcium levels in hypertensive
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