Abstract
Efforts to understand how prolonged spaceflight affects changes in calcium homeostasis and bone formation–resorption were pursued in laboratory rats during three joint NASA-Soviet Biosatellite Flights of 18.5–22 days duration (Cosmos 605, 782, 936). The appendicular weight-bearing bones, femurs and tibias, suffered reduction in the rate of cortical and trabecular bone growth and in their ash content but certain of the forelimb elements were spared. In the Cosmos 1129 flight (September–October 1979), there was an opportunity to examine the effect of null gravity on the intergrated growth and remodeling of a nonweight-bearing bone—the mandible and its teeth. Three groups of 5–7 SPF male rats (270–320 grams) were injected with 1.0 mg/kg Declomycin 3 days prior to being loaded into a block modules of 5 cages mounted in a modified Soyez spacecraft. The animals were then launched into orbit for a period of 18.5 days. After autopsy, the mandibles of rats were recovered. The left jaw was divided into three regions: the premolar, molar, and postmolar regions.
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