Abstract
The purpose of this study was the synthesis of two types of biodegradable materials with synthetic polymers (PLGA) or natural polymers (collagen) and hydroxyapatite, followed by determination of the encapsulation percentage of the drug in the polymer. Regardless of the chosen method, the percentage of the encapsulated drug was found to be quite high: 15.92% in the Coll-HA-Genta material and 19.59% respectively in the PLGA-Genta biocomposite. The therapeutic value of gentamicin was improved by encapsulating it in delivery systems, contributing to sustained release for a long time (about 30 days).
Highlights
The purpose of this study was the synthesis of two types of biodegradable materials with synthetic polymers (PLGA) or natural polymers and hydroxyapatite, followed by determination of the encapsulation percentage of the drug in the polymer
Gentamicin has been successfully used since 2011 by impregnation in bone cement in the treatment of infections in articular arthroplasty [10]; The local delivery of gentamicin in the treatment of osteomyelitis has been developed in the last decade both for prophylactic treatment and for infectious treatment, but using non-biodegradable polymers such as polymethylmethacrylate (PMMA) or calcium sulphate [11]; FT-IR characterization of PLGA-Genta and Coll-HA-Genta In pure gentamicin, the amide groups were observed at
In all the spectra we observed in the region 2750-3450 cm-1 broad band corresponding to hydroxyl groups from gentamicin sulphate structure [14]
Summary
The purpose of this study was the synthesis of two types of biodegradable materials with synthetic polymers (PLGA) or natural polymers (collagen) and hydroxyapatite, followed by determination of the encapsulation percentage of the drug in the polymer. Regardless of the chosen method, the percentage of the encapsulated drug was found to be quite high: 15.92% in the Coll-HA-Genta material and 19.59% respectively in the PLGAGenta biocomposite. The field of biocomposite based on collagen and hydroxyapatite has been amazingly evolved over the last decades due to its remarkable features, being biomaterials very similar to the natural bone [6]. The research goal was to synthesize two types of composite materials (collagen-hydroxyapatite-antibiotic and PLGA-antibiotic) and to carry out a series of physicochemical characterizations (FT-IR, HPLC) in order to determine the loading capacity of the drug and in vitro release profile
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