Bone formation by minimodeling is more active than remodeling after parathyroidectomy

Abstract

Bone formation using the process known as minimodeling forms only lamellar bone in the absence of prior bone resorption even in uremic patients. In patients undergoing parathyroidectomy for secondary hyperparathyroidism, we compared the contribution of minimodeling to remodeling during the change in bone volume. Iliac bone biopsies were used to measure parameters related to minimodeling and remodeling before, at 3 to 4 weeks and 10 to 12 weeks after parathyroidectomy. Osteoblast surface due to minimodeling was greater than the entire bone osteoblast surface before and at 10 to 12 weeks after parathyroidectomy, but not 3 to 4 weeks after surgery. Minimodeling significantly increased osteoid volume 3 to 4 weeks after parathyroidectomy. The rate of change of osteoid volume by minimodeling was greater than that of osteoid volume during the first 3 to 4 weeks after surgery, indicating osteoid formation was more active at the minimodeling surface than at the entire bone surface. Furthermore, higher mineral apposition rates at the minimodeling sites than at remodeling sites yielded increased minimodeling bone volume at 10 to 12 weeks after surgery. Our results show that bone formation by minimodeling is more active than by remodeling and accounts, in part, for the increase of bone volume following parathyroidectomy.