Abstract
In this study, the feasibility of assessing the chemical composition in bone using the multi-wavelength photoacoustic analysis (MWPA) method was investigated. By illuminating a bone specimen using laser light with a wavelength tunable over an optical spectrum from 680 nm to 950 nm, the optical absorption spectrum of the bone was acquired. Then, with the optical absorption spectra of all the optically absorbing chemical components in the bone known, a spectral unmixing procedure was performed to quantitatively assess the relative content of each chemical component. The experimental results from porcine rib bones demonstrated that the contents of the chemical components, including not only non-organic materials such as minerals and water but also organic materials including oxygenated hemoglobin, deoxygenated hemoglobin, lipid, and collagen, can all be assessed by MWPA. As the chemical composition in the bone is directly associated with functional and metabolic activities, the finding from this study suggests that the MWPA method could offer a new diagnostic tool for the non-invasive evaluation of bone health.
Highlights
The number of patients with osteoporosis, a serious public health threat with significant physical, psychological, and economic impacts, is expected to grow, mainly due to the increase in the aging population worldwide
The Quantitative ultrasound (QUS) bone assessment methods are usually based on the measurements of sound velocity (SOS) and broadband ultrasound attenuation (BUA) through a
This study aimed at validating the feasibility of the multi-wavelength PA analysis (MWPA) method in quantifying the chemical information in the trabecular bones with differing bone mineral density (BMD)
Summary
The number of patients with osteoporosis, a serious public health threat with significant physical, psychological, and economic impacts, is expected to grow, mainly due to the increase in the aging population worldwide. The bone mineral density (BMD) is reduced, bone microarchitecture (BMA) deteriorates, and the amount and variety of proteins in bone are altered. Most clinically used non-invasive assessment methods are based on the use of. X-ray or ultrasound [1,2] These methods, often used to measure bone mineral density (BMD) and some mechanical properties, have limited sensitivity to monitor the chemical or molecular changes in the bone that result from disease or aging. X-ray-based techniques use ionizing radiation, which is not ideal for pediatric applications or long-term repetitive monitoring. The QUS bone assessment methods are usually based on the measurements of sound velocity (SOS) and broadband ultrasound attenuation (BUA) through a
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
