Abstract
Objective The aim of the study is to evaluate the effects of multilaminated small intestinal submucosa (mSIS) combined with bone substitute material to repair peri-implant defects during guided bone regeneration procedures. Methods Twelve implants were placed in bilateral lower premolars of three beagle dogs, and a peri-implant buccal bone defect (3 mm width and 4 mm height) was created at each implant site. A total of 12 sites were filled with a particulate bone substitute material and then randomly divided into three treatment groups: covered by mSIS membrane (mSIS group), covered by collagen membrane (BG group), and no treatment (control group), each group of four sites. After 12 weeks of healing, all of the animals were euthanized and dissected blocks were obtained for micro-computed tomography (micro-CT) and histological analyses. Results Micro-CT results revealed similar horizontal width of augmented tissue and new bone formation between mSIS and BG groups (P < 0.05). Histological analyses revealed that the differences in horizontal widths of newly formed bone and bone-to-implant contact between mSIS and BG groups were not significant (P > 0.05). All of these parameters were significantly different from those in the control group (P < 0.05). Conclusions These findings confirmed that mSIS combined with the bone substitute material enhanced bone regeneration in peri-implant defects, in a manner similar to that of a collagen membrane.
Highlights
Insufficient alveolar bone volume after tooth extraction often leads to bone defects around the implant, which influences the long-term prognosis of the implantation treatment [1, 2]. e guided bone regeneration (GBR) technique, which combines different barrier membranes with the bone substitute material, has become the standard procedure in bone augmentation treatment of peri-implant dehiscence-type defects [3,4,5]
Peri-implant defects often occur after implant placement when the width of the alveolar bone is insufficient. e use of the GBR technique to place the bone substitute material combined with the collagen membrane promotes new bone formation in periimplant defects [18, 19]
As in previous studies that have used a similar protocol in a canine peri-implant defect model [22, 23], new bone formation was consistent in the multilaminated small intestinal submucosa (mSIS) and BG groups in our study, indicating that the bone defect model we established is a valid experimental model
Summary
Insufficient alveolar bone volume after tooth extraction often leads to bone defects around the implant, which influences the long-term prognosis of the implantation treatment [1, 2]. e guided bone regeneration (GBR) technique, which combines different barrier membranes with the bone substitute material, has become the standard procedure in bone augmentation treatment of peri-implant dehiscence-type defects [3,4,5]. E guided bone regeneration (GBR) technique, which combines different barrier membranes with the bone substitute material, has become the standard procedure in bone augmentation treatment of peri-implant dehiscence-type defects [3,4,5]. Bioabsorbable collagen membrane is the most frequently used barrier membrane in GBR treatments [6, 7]. E extracellular matrix (ECM), which retains collagen and various signaling molecules containing glycosaminoglycans, glycoproteins, and abundant growth factors [8], has been used in the GBR technique for the purpose of building a tissue engineering scaffold [9,10,11,12]. Porcine-derived small intestinal submucosa (SIS) is an acellular, naturally derived ECM material from the submucosal layer of porcine intestinal tissue [13, 14]. SIS has demonstrated osteoinductive potential for use in the GBR procedure [16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
