Bone and calcium metabolism associated with malignancy. Tumor-induced osteomalacia.

Abstract

Tumor-induced osteomalacia(TIO)is a paraneoplastic syndrome caused by excessive production and secretion of fibroblast growth factor 23(FGF23)from causative tumors which induces hypophosphatemia and osteomalacia. Mesenchymal benign tumors in bone or soft tissue are the most frequent causes for TIO. The first choice treatment of TIO is complete resection of the responsible tumors. In patients whose tumors cannot be completely removed, phosphate salt and active vitamin D are usually prescribed. The effect of anti-FGF23 monoclonal antibody that inhibits the actions of FGF23 is being tested in clinical trials.