Abstract
A highly specific and sensitive radioimmunoassay was developed to measure the regional distribution of bombesin-like peptides in rat brain. Extracts derived from the hypothalamus had the highest levels of bombesin-like immunoreactivity. Intermediate levels of bombesin-like immunoreactivity were observed in the thalamus and midbrain; low levels in the parietal cortex, striatum, hippocampus and medulla pons, whereas few, if any, bombesin-like peptides were detected in the cerebellum and pituitary. Using gel filtration techniques, one major and two minor peaks of immunoreactivity were derived from the hypothalamus, thalamus and midbrain. These endogenous bombesin-like peptides may play an important neuroregulatory role in the central nervous system.
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