Abstract
Using extracellular single-unit recording in brain tissue slices, the effects of bombesin (Bomb), neurotensin (NT), and their analogs on hypothalamic arcuate (ARC) neurons were tested in this study. Adult ovariectomized Sprague-Dawley rats were used for obtaining the brain slices. Both Bomb and NT in pmol ranges stimulated nearly 70% of ARC neurons tested and the effects were all very significant. [D-Trp 11]-NT, a NT analog, behaved more like an analog of NT instead of an antagonist, although [Leu 13-ψ(CH 2NH)-Leu 14]-Bomb, a Bomb receptor antagonist, could not block most of Bomb's effects on ARC neurons. The significant effects of Bomb and NT shown in this report indicate that both peptides may play significant roles in the neuroendocrine control system.
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