Abstract
Bombax costatum Pellegr. and Vuillet Stem Bark Extract Prevents Paracetamol and Carbon Tetrachloride-Induced Liver Injury in Rats
Highlights
The liver is an important organ in the body involved in homeostasis, metabolism of drugs, toxins and food substances, and is one of the major organs prone to oxidative insults by the attack of reactive oxygen species.[1]
There is no scientific report validating the use of the stembark in treatment of liver diseases and in this regard, this study was aimed at investigating the hepatoprotective and antioxidant potentials of the methanol extract of Bombax costatum stem bark against paracetamol and carbon tetrachloride-induced liver injury in rats
A small proportion of paracetamol is metabolized by cytochrome P450 to form the highly reactive species, N-acetyl-p-benzoquinone imine (NAPQI), which under normal conditions is readily detoxified by conjugation with glutathione (GSH) to form harmless water soluble mercapturic acid, which undergoes renal excretion.[20]
Summary
The liver is an important organ in the body involved in homeostasis, metabolism of drugs, toxins and food substances, and is one of the major organs prone to oxidative insults by the attack of reactive oxygen species.[1]. According to the World Health Organization, about 80% of the population in developing countries rely on traditional medicine for their healthcare needs.[6]
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