BOLD MRI: a tool for predicting tumor therapy outcome based on tumor blood oxygenation and vascular function

Abstract

We believe that oxygen-sensitive MRI can be used to evaluate tumor hypoxia so that therapy may be individualized and optimized for the characteristics of an individual patient. Specifically, we foresee a simple test based on breathing hyperoxic gas to characterize tumor hypoxia and the potential for modulating tumor hypoxia and hence therapeutic response. Radiology has become the mainstay for clinical diagnosis and together with pathology underpins clinical medicine. Imaging has come a long way from the revolutionary, but crude x - rays