Abstract
Most current HIFU approaches to treat liver tumors rely on thermal tissue ablation. Challenges still remain that prevent widespread clinical application of this technology including long treatment times, side effects such as skin burns, attenuation and aberration by ribs, heat diffusion and perfusion. Recently, a new method named boiling histotripsy (BH) was developed at the UW/MSU to address these challenges. BH applies a sequence of millisecond-long pulses with high-amplitude shocks that rapidly heat tissue and initiate boiling within each pulse. Interaction of shocks with the resulting vapor cavity leads to tissue fractionation into subcellular debris. Multiple BH lesions can be generated to sonicate clinically relevant tissue volumes. The goal of this study was to evaluate the feasibility of a clinical HIFU system to treat tissue with BH and to develop exposure protocols for such treatments with real-time and post-treatment MR imaging.
Highlights
Background/introduction Most current HIFU approaches to treat liver tumors rely on thermal tissue ablation
The goal of this study was to evaluate the feasibility of a clinical HIFU system to treat tissue with boiling histotripsy (BH) and to develop exposure protocols for such treatments with realtime and post-treatment MR imaging
Using electronic steering transverse to the beam axis, volumetric lesions were generated by treating circles of 2, 4, 6, and 8 mm radii, with 2 mm separation between focal points along each
Summary
Background/introduction Most current HIFU approaches to treat liver tumors rely on thermal tissue ablation. Challenges still remain that prevent widespread clinical application of this technology including long treatment times, side effects such as skin burns, attenuation and aberration by ribs, heat diffusion and perfusion. A new method named boiling histotripsy (BH) was developed at the UW/MSU to address these challenges. BH applies a sequence of millisecondlong pulses with high-amplitude shocks that rapidly heat tissue and initiate boiling within each pulse. Interaction of shocks with the resulting vapor cavity leads to tissue fractionation into subcellular debris. Multiple BH lesions can be generated to sonicate clinically relevant tissue volumes. The goal of this study was to evaluate the feasibility of a clinical HIFU system to treat tissue with BH and to develop exposure protocols for such treatments with realtime and post-treatment MR imaging
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