Body temperature rhythms, cold tolerance, and fever in young and old rats of both genders

Abstract

The circadian rhythm of body temperature (CTR) of male and female rats living at 23°C, as well as their body temperature response to a yeast injection or to a 2-h exposure to 0°C, was investigated by telemetry. Young rats had a clear CTR with a mean nocturnal peak of 38.0 ± 0.1°C and diurnal trough of 36.2 ± 0.1°C. Older rats, starting at about 18 months of age, tended to have poor (that is, lower amplitude) rhythms. Mean daily body temperature was 37.1 ± 0.2°C at all ages. After exposure to the cold, the body temperature of young rats, old rats with a strong CTR, and old rats with a poor CTR changed in the ranges of −0.3 to +1.5°C, −3.1 to +0.7°C, and −5.2 to +0.4°C, respectively. This indicates that old animals, especially but not exclusively those with poor CTRs, are less resistant to cold stress. On the other hand, the capacity to develop a fever in response to a yeast injection was equivalent in the three groups of animals, although females had a smaller response than males. It is concluded that the process of aging does not have a generalized debilitating effect on temperature regulation in rats. Rather, aging seems to affect individual components of the thermoregulatory system differentially.