Body size in adolescence and future risk of Aortic disease: a nationwide cohort study of Swedish men

Abstract

Abstract Background To improve cardiovascular disease prevention, knowledge of early key risk factors for aortic disease (AD), especially those that are modifiable such as overweight and obesity, is essential. Therefore, we aimed to determine whether measures of body size, including body mass index (BMI), body surface area (BSA) and body height in adolescent men is associated to AD later in life. Methods Register-based cohort study of conscripts (n=1,575,909; mean age at baseline, 18.3 years) who enlisted during 1968–2005 in Sweden. Follow-up was done through linkage to the nationwide Swedish inpatient- and cause of death registries. Risk of AD (hospitalization for Aortic aneurysm or aortic dissection) during follow-up (5–48 years) was calculated with cox proportional hazard models. Results During follow-up there were 8185 cases of AD. Incidence rates (per 100000 person years) increased with increasing body size measures; BSA 14.19 (95% CI, 13.6–14.8) for Q1 vs 19.36 (18.6–20.2) for Q4; BMI 15.89 (15.2–16.6) for Q1 vs. 16.89 (16.2–17.6) for Q4; and body height 13.45 (95% CI, 12.9–14.1) for Q1 vs 19.93 (95% CI, 19.1–20.8) for Q4. Compared to the lowest, the highest quartile of BSA and body height was associated with increased risk of AD (adjusted HR (aHR) 1.95 (95% confidence interval 1.83–2.08) and 1.72 (1.62–1.83) respectively). For BMI, the corresponding aHR was 1.40 (1.31–1.49, Figure 1). Conclusion Large body size in early adulthood is associated with risk for aortic disease later in life. The pathophysiological mechanisms remain uncertain and warrants further investigation. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Swedish state under the agreement concerning research and education of doctors [grant number ALFGBG-427301]; the Swedish Society for Physicians, the Health & Medical Care Committee of the Regional Executive Board, Region Västra Götaland, Sweden, and the Swedish Heart and Lung Foundation [grant number 2015-0438]; the Swedish Research Council [grant numbers 2013-5187 (SIMSAM), 2013-4236]; and the Swedish Council for Health, Working Life and Welfare (FORTE) [grant numbers 2013-0325]