Body roundness index is a superior indicator to associate with the cardio\u2010metabolic risk: evidence from a cross\u2010sectional study with 17,000 Eastern-China adults

Jinjian Xu,Ziqi Jin,Qiong Wu,Yimin Zhu,Zhijian Li,Yaohan Zhou,Liqun Zhang

doi:10.1186/s12872-021-01905-x

Abstract

BackgroundTo investigate the ability of body shape index (ABSI), body roundness index (BRI), waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body adiposity index (BAI) for predicting non-adipose cardio-metabolic risk.MethodsA total of 17,360 Chinese subjects aged 18–95 years old who escaped cardiovascular disease (CVD) or diabetes were recruited in the cross-sectional study. Anthropometric and biochemical parameters were assessed. Receiver operating characteristic curve (ROC) and multinomial logistic regression were conducted to examine the association of anthropometric indicators with cardio-metabolic risk factors.ResultsThe mean age of subjects were 53.7(13.1) years, 41.6 % were males. The areas under the curve (AUC) demonstrated that WC, BMI, WHR, WHtR and BRI were able to predict high cardio-metabolic risk (AUC > 0.70). Meanwhile, multinomial logistic regression showed BRI was significantly associated with high cardio-metabolic risk (OR 3.27, 95% CI 3.01–3.55). The optimal cut-off values of BRI for high cardio-metabolic risk were (< 60 y: 3.49 vs. ≥60 y: 3.46) in males and (< 60 y: 3.47 vs. ≥60 y: 3.60) in females.ConclusionsWC, BMI WHR, and WHtR were potential obesity indicators in discriminating high cardio-metabolic risk, while BAI or ABSI was not. Moreover, BRI revealed superior predictive capacity and significant association with accumulated cardio-metabolic risk factors.

Highlights

To investigate the ability of body shape index (ABSI), body roundness index (BRI), waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body adiposity index (BAI) for predicting non-adipose cardio-metabolic risk
Metabolic syndrome (MetSy) is a serious metabolic disorder consisting of obesity, hypertension, abnormal metabolism of lipoprotein and plasma glucose, which plays a vital role in the development of atherosclerotic heart disease, stroke and diabetes mellitus [1,2,3]
Basic characteristics of the objects According to the number of cardio-metabolic risk factors, subjects were divided into non-metabolic risk group, low metabolic risk group (< 3) and high metabolic risk group (≥ 3), and the differences of basic characteristics were analyzed by the presence of cardio-metabolic risk factors (Table 1)

Summary

Introduction

To investigate the ability of body shape index (ABSI), body roundness index (BRI), waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body adiposity index (BAI) for predicting non-adipose cardio-metabolic risk. MetSy was considered as an intermediate trait in the progression of severe cardiovascular disease (CVD) [8, 9] and can contribute to the risk of diabetes[10, 11]. The residual components of MetSy that excluding obesity were clustered as non-adipose cardio-metabolic risk factors will be more suitable for investigating the progress of cardiovascular disease or other adverse traits [4, 20]. Previous studies revealed that an alteration of SUA level was associated with abnormal glucose and hyperuricemia, and it was considered to be a risk factor for MetSy or metabolic disorders [25,26,27]

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Conclusion