Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients.

Jinwoo Kang,Jae Woo Lee,Ji Kon Ryu,Yong-Tae Kim,Young Hoon Choi,Sang Hyub Lee,Jun Hyuk Son,Woo Hyun Paik,Jin Ho Choi,Gianfranco D Alpini

doi:10.1371/journal.pone.0195118

Abstract

BackgroundThe impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy.MethodsBetween January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.ResultsMedian overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23–24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436–0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168–1.986, p = 0.046) was associated with a shorter in overall survival.ConclusionOverweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients.

Highlights

Biliary tract cancer (BTC) is a rare but fatal neoplasm that arises from biliary epithelium
Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that body mass index (BMI), stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival
No studies have evaluated BMI and body weight changes as prognostic factors in patients who underwent chemotherapy, which is the mainstay of treatment for unresectable BTCs. Taking these points into consideration, we evaluated the association between BMI and clinical outcomes including overall and progression-free survival and whether body weight changes can be a prognostic factor for advanced BTC patients receiving palliative chemotherapy

Summary

Background

The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy. Data Availability Statement: The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the Supporting Information files.

Methods

Results

Introduction

Discussion