Abstract
Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia.
Highlights
In the heart failure population, overweight individuals are associated with lower mortality, termed the obesity survival paradox
There was no relationship between body mass index (BMI) as a continuous variable and mortality adjusted for age, sex, and cardiac stage at diagnosis
There was a statistically significant relationship between higher BMI (≥ 25 kg/ m2) and a lower likelihood of achieving a cardiac response, Figure 1. In this small cohort of patients with AL cardiac amyloidosis, there was no relationship between BMI and mortality, but patients with a higher BMI were significantly less likely to achieve a cardiac response
Summary
We conducted a single tertiary center retrospective study of consecutive ambulatory patients with cardiac AL amyloidosis, referred between 1/1/2009 and 09/30/2018. We collected baseline demographics, including age, race, gender, cardiac stage, height, and weight prior to treatment. We recorded important clinical endpoints from the electronic medical record including all-cause mortality, and hematologic and cardiac response after first-line treatment. For analysis of cardiac response, patients were grouped into response or no response (progression was categorized as “no response”). Patients were analyzed with BMI as a continuous variable with respect to mortality and among BMI cohorts with respect to cardiac response and hematologic response. Logistic regression models were constructed to examine the association between high BMI (defined as BMI ≥ 25 kg/ m2) and cardiac or hematological response.
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