Abstract
Aims To investigate the influence of body mass index (BMI) and its change from adolescence to adulthood (ΔBMI) on the risk of metabolic syndrome (MetS) in early adulthood. Methods We selected 931 students from 12 to 16 years of age in Liaoyang City, China. Ninety-three participants from 18 to 22 years of age with complete baseline data were available for follow-up after 5 years. Statistical analysis determined the relationship of MetS at follow-up with baseline BMI (BMIb), ΔBMI, and follow-up BMI (BMIf). Results ΔBMI was positively correlated with the change of waist circumference (ΔWC), systolic blood pressure (ΔSBP), triglycerides (ΔTG), uric acid, and glycosylated hemoglobin (ΔHbA1c) in follow-up (p < 0.05). For every 1 kg/m2 increase in BMIb, ΔBMI, and BMIf, the risk of MetS at follow-up increased 1.201-fold, 1.406-fold, and 1.579-fold, respectively. Both BMIb and ΔBMI were predictive of MetS at follow-up, with prediction thresholds of 23.47 kg/m2 and 1.95 kg/m2. The participants were divided by the predicted BMIb and ΔBMI threshold values into four study groups. Interestingly, the group with lower BMI but a higher increase in BMI presented the same metabolic derangements and Mets% of the group with higher BMI but lower Δ BMI. Conclusion Both BMI of adolescence and ΔBMI were predictive of MetS and cardiovascular risk factors in adulthood. Control of both variables in adolescents would be more effective in decreasing the risk of MetS in young adults than control of BMI alone.
Highlights
Metabolic syndrome (MetS) includes a group of conditions, central obesity, impaired glucose tolerance, hypertension, and abnormal lipid metabolism that are associated with insulin resistance and increases the risk of cardiovascular diseases [1, 2]. e occurrence of MetS and type 2 diabetes in young adults has been increasing along with an increase in obesity among adolescents [3, 4]
Studies conducted in the west have reported that childhood obesity increased the risk of metabolic diseases in adulthood and that an increase in the body mass index (BMI) from childhood through adolescence was correlated with the development of MetS as an adult [6,7,8] and was positively associated with early adult ischemic stroke [9]
After partial correlation analysis to account for the effects of age and gender (Table 2), it was found that ΔBMI was negatively correlated with BMIb and positively correlated with ΔWC, ΔSBP, ΔTG, Δuric acid, and ΔHbA1c. erefore, we corrected for the effect of BMIb as a confounding factor in the analysis of the effect of ΔBMI on MetS at follow-up
Summary
Metabolic syndrome (MetS) includes a group of conditions, central obesity, impaired glucose tolerance, hypertension, and abnormal lipid metabolism that are associated with insulin resistance and increases the risk of cardiovascular diseases [1, 2]. e occurrence of MetS and type 2 diabetes in young adults has been increasing along with an increase in obesity among adolescents [3, 4]. Studies conducted in the west have reported that childhood obesity increased the risk of metabolic diseases in adulthood and that an increase in the body mass index (BMI) from childhood through adolescence was correlated with the development of MetS as an adult [6,7,8] and was positively associated with early adult ischemic stroke [9]. Increasing BMI in adulthood has been associated with an increased risk of cardiovascular disease, type 2 diabetes, MetS, and other chronic conditions [11]. Adolescents between 12 and 16 years of age living in Liaoyang City in northeastern China were followed for 5 years to determine the impact of BMI in adolescence and its change from adolescent through adult on the development of MetS and other cardiovascular risk factors in early adulthood. Adolescents between 12 and 16 years of age living in Liaoyang City in northeastern China were followed for 5 years to determine the impact of BMI in adolescence and its change from adolescent through adult on the development of MetS and other cardiovascular risk factors in early adulthood. e objective was to provide a theoretical basis for adolescents to control weight and prevent MetS
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
