Abstract
Curative surgical resection (CSR) remains the most effective therapeutic intervention for patients with hepatocellular carcinoma (HCC); however, frequent post-surgical recurrence leads to high cancer related mortality. This study aimed to clarify the role of body mass index (BMI) and serum cholesterol level in predicting post-surgical outcomes in HCC patients after CSR. A total of 484 HCC patients including 213 BMIhigh and 271 BMIlow patients were included. Overall survival (OS) and recurrence-free survival (RFS) rates were examined in patients with differential BMI and serum cholesterol level. The analysis showed that significant different 1-, 3- and 5-year cumulative OS rates (P-value=0.015) and RFS rate (P-value=0.010) between BMIlow and BMIhigh patients. Further analysis in groups with differential serum cholesterol levels among BMIlow and BMIhigh patients indicated that the BMIlow/Chollow patients exhibited the significant lower cumulative OS and RFS rates in comparison with the remaining subjects (P-value=0.007 and 0.039 for OS and RFS rates, respectively). In conclusion, the coexistence of low BMI and low serum cholesterol level could serve as prognostic factors to predict post-operative outcomes in HCC patients undergoing surgical hepatectomy.
Highlights
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancerrelated deaths worldwide [1]
The results indicated that the obese patients have a high diabetic incidence and high cholesterol levels as others factor showed no significant difference between BMIhigh and BMIlow groups. *: P-value < 0.05
body mass index (BMI) is significantly correlated with surgical outcome after curative hepatectomy To clarify the association between BMI and surgical outcome, Overall survival (OS) and recurrencefree survival (RFS) rates in BMIlow and BMIhigh groups were analyzed
Summary
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancerrelated deaths worldwide [1]. Frequent recurrence of HCC in patients undergoing surgical treatment procedure, such as curative hepatic resection, still results in high cancer related mortality. A recent study has shown that a number of risk factors, such as preoperative serological C-reactive protein (CRP) level, correlated with cancer recurrence in patients with HCC after hepatic resection, revealing the possibility to predict surgical outcome by preoperative clinical physiological parameters [4]. The candidate index to predict surgical outcome would need to be common and easy to interpret. While body mass index (BMI) is the most accessible information from routine checkouts, testing the correlation of patients’ BMI and HCC prognosis is of great interest
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