Abstract
BackgroundOur study evaluated the association between body mass index (BMI) and absolute lymphocyte count (ALC) in breast cancer patients and healthy females. Additionally, we determined the prognostic value of these factors in breast cancer.MethodsWe retrospectively identified 1225 primary invasive breast cancer patients and 35,991 healthy females. Factors including BMI and complete blood count associated with disease-free survival (DFS) were assessed using a multi-variable Cox proportional hazard model.ResultsBMI and ALC were positively correlated in breast cancer patients and healthy females (both P < 0.001). In multi-variable analysis, overweight or obese participants had worse DFS (hazards ratio [HR], 1.98; 95% confidence interval [CI], 1.34–2.92; P = 0.001) than underweight or normal-weight individuals, but patients with high ALC had better DFS than those with low ALC (HR, 0.43; 95% CI, 0.29–0.65; P < 0.001). After risk stratification according to BMI/ALC, high-risk patients with high BMI/low ALC had worse DFS than others (HR, 2.48; 95% CI, 1.70–3.62; P < 0.001).ConclusionsBMI and ALC were positive correlated, but their effect on breast cancer prognosis was opposite. Patients with high BMI/low ALC had worse DFS than others. Underlying mechanisms for effect of BMI/ALC on breast cancer prognosis should be studied in the future.
Highlights
Our study evaluated the association between body mass index (BMI) and absolute lymphocyte count (ALC) in breast cancer patients and healthy females
white blood cells (WBCs), platelet count and monocyte count was increased in patients with overweight or obese compared to patients with normal weight. (WBC, P < 0.001; platelet, P < 0.001; monocyte, P = 0.001; Supplementary Fig. S2)
We analysed complete blood count (CBC) according to BMI in healthy females to compare results with those of breast cancer patients
Summary
Our study evaluated the association between body mass index (BMI) and absolute lymphocyte count (ALC) in breast cancer patients and healthy females. (HER2), grade and Ki-67 labelling index (LI) affect disease prognosis.[3,4] Currently, significant efforts are being made to develop methods for the accurate prediction of breast cancer prognosis Obesity is another major global health concern; in South Korea, >60% women aged >40 years are overweight or obese.[5] Obesity is an important risk factor for diabetes, cardiovascular disease and kidney disease; it has been recently recognised as a risk factor for breast cancer.[6] hormones, adipocytokines and inflammatory cytokines have been identified as potential mediators, the biological mechanisms that explain the association between obesity and breast cancer survival have not been conclusively established.[7] Body mass index (BMI), calculated using body weight and height, is the most widely used measure for the degree of obesity.[8]
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