Abstract
The dual energy x-ray absorptiometry (DEXA) technique to measure bone density may also provide estimates of body composition, abnormalities of which are a well recognized consequence of growth hormone deficiency. To assess the precision of the method in clinical practice, we have compared estimates of total body water by DEXA (Hologic QDR 1000/W) with those obtained from skinfold thickness and bioelectrical impedance measurements in 10 patients aged (range) 14.0 to 17.9yrs, receiving growth hormone therapy. Total body water (kg) derived from estimates of lean tissue (assuming 73% hydration) by DEXA was compared with those values obtained by skinfold and impedance measurements as follows:we conclude, that given the small numbers of patients studied thus far, estimates of body composition by DEXA have a high degree of precision when compared to those obtained from the skinfold thickness method though less so when compared with bioelectrical impedance. Measurement of body composition by DEXA may therefore be of value in the assessment of the effects of growth hormone therapy on body composition.
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