Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome.

Rodrigo De Azeredo Siqueira,Marilia Martins Guimarães,Aluana Santana Carlos,Joana Costa D'Avila,Estela Luz Alves,Maria Lucia Fleiuss De Farias,Adalgiza Mafra Moreno,Laura Maria C Mendonça

doi:10.20945/2359-3997000000287

Abstract

The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups. We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment-insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively). We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement.

Highlights

Turner’s syndrome is a disorder that affects females and is characterized by a complete or partial absence of one X chromosome associated with typical phenotypic features [1]
We observed that body composition affects postprandial triglyceride levels in both groups of patients with Turner’s syndrome
We found no association between the homeostatic model assessment–insulin resistance (HOMA-IR) index and postprandial triglyceride levels in patients with Turner’s syndrome

Summary

Introduction

Turner’s syndrome is a disorder that affects females and is characterized by a complete or partial absence of one X chromosome associated with typical phenotypic features [1]. Postprandial lipemia in Turner’s syndrome of lipid metabolism, including postprandial plasma triglyceride (TG) levels, have not been studied in these patients. No long-term studies have assessed the effect of combined hormone replacement therapy on lipid metabolism in patients with Turner’s syndrome or otherwise healthy women of comparable age [15].

Results

Conclusion